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secobarbital will lower the extent or effect of amiodarone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.secobarbital will decrease the extent or effect of atogepant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Advised atogepant dosage with concomitant utilization of robus